Mitochondrial function across sex and age
Although different organs age at different times based on varies factors, the mechanisms underlying shared and organ selective functional changes across the lifespan, however, still remains poorly understood.
The researchers carried out transcriptional analysis of mitochondrial activity in 33 different tissues in young (2.5 months) and old (20 months) mice of both sexes as mitochondria are power houses and provide energy for various cellular processes.
The authors found that mitochondrial activity varies widely across tissues, biological sex is a significant but minor contributor to mitochondrial respiration, and its contributions are tissue-specific, age is a dominant factor affecting mitochondrial activity, age effects can be sex- and tissue-specific, while aging alters the functional trajectories of mitochondria in a majority of tissues, some are remarkably resilient to age-induced changes.
